Don't forget the electrical eels! The history of TMS can be traced back to earlier forms of neuromodulation and the ancient practice of using electrical eels for pain relief. Transcranial magnetic stimulation (TMS) therapy is a highly effective anti-depression drug treatment in which short magnetic pulses are used to stimulate nerve cells within the brain. It has been in use since 1985, but the path toward this revolutionary non-invasive treatment has involved much time, scientific research, and technological advancement.